Changes in withdrawal severity were assessed by using the BZD Withdrawal Scale (BWS). Methods: Seven-day FLU 1 mg/day subcutaneously injected through an elastomeric pump and BZDs lormetazepam, clonazepam, and lorazepam were assessed by HPLC-MS/MS in serum of patients before and after 4 and 7 days of FLU continuous infusion treatment. The aim of this study was to confirm FLU efficacy for reducing BZD withdrawal syndrome by means of continuous elastomeric infusion, correlated to drugs plasma level and patients' compliance. Studies in chronic users who discontinued BZD in a clinical setting suggested that multiple slow bolus infusions of FLU reduce BZD withdrawal symptoms. 3Department of Internal Medicine, Addiction Unit, Verona University Hospital, Verona, ItalyĪn effective approach in the treatment of benzodiazepine (BZD) overdosing and detoxification is flumazenil (FLU).2Forensic Toxicology Laboratory, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.1Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Anna Benini 1, Rossella Gottardo 2, Cristiano Chiamulera 1, Anna Bertoldi 3, Lorenzo Zamboni 3 * and Fabio Lugoboni 3
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